Polymyxins and bacterial membranes: a review of antibacterial activity and mechanisms of resistance
C Ayoub Moubareck - Membranes, 2020 - mdpi.com
Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes
GS Martin - Expert review of anti-infective therapy, 2012 - Taylor & Francis
Sepsis has been around since the dawn of time, having been described for more than 2000
years, although clinical definitions are recent. The consensus sepsis definitions have …
years, although clinical definitions are recent. The consensus sepsis definitions have …
Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis
Early recognition and treatment of sepsis are linked to improved patient outcomes. Machine
learning-based early warning systems may reduce the time to recognition, but few systems …
learning-based early warning systems may reduce the time to recognition, but few systems …
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials
P Sinha, VE Kerchberger, A Willmore… - The Lancet …, 2023 - thelancet.com
Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
Host innate immune responses to sepsis
WJ Wiersinga, SJ Leopold, DR Cranendonk… - Virulence, 2014 - Taylor & Francis
The immune response to sepsis can be seen as a pattern recognition receptor-mediated
dysregulation of the immune system following pathogen invasion in which a careful balance …
dysregulation of the immune system following pathogen invasion in which a careful balance …
Pathophysiology of ischemic acute kidney injury
AA Sharfuddin, BA Molitoris - Nature Reviews Nephrology, 2011 - nature.com
Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …
Antiinflammatory action of glucocorticoids—new mechanisms for old drugs
T Rhen, JA Cidlowski - New England Journal of Medicine, 2005 - Mass Medical Soc
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …
An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies
Abstract HMGB1 (High-Mobility Group Box-1) is a nuclear protein that acts as an
architectural chromatin-binding factor involved in the maintenance of nucleosome structure …
architectural chromatin-binding factor involved in the maintenance of nucleosome structure …
Acute renal failure and sepsis
RW Schrier, W Wang - New England Journal of Medicine, 2004 - Mass Medical Soc
Acute Renal Failure and Sepsis | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Role of C5a in inflammatory responses
RF Guo, PA Ward - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract The complement system not only represents an effective innate immune
mechanism of host defense to eradicate microbial pathogens, but it is also widely involved in …
mechanism of host defense to eradicate microbial pathogens, but it is also widely involved in …