Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Interest in CD8+ T cells and B cells was initially inspired by observations in multiple
sclerosis rather than in animal models: CD8+ T cells predominate in multiple sclerosis …

This protocol details a method to actively induce experimental allergic encephalomyelitis
(EAE), a widely used animal model for studies of multiple sclerosis. EAE is induced by …

Multiple sclerosis (MS) is considered a prototypic autoimmune disease of the central
nervous system (CNS). A complex genetic background with the HLA-DR15 haplotype as the …

Oligodendrocytes myelinate axons for rapid impulse conduction and contribute to normal
axonal functions in the central nervous system. In multiple sclerosis, demyelination is …

Experimental allergic encephalomyelitis (EAE) is a widely used animal model of the human
demyelinating disease multiple sclerosis. EAE is initiated by immunization with myelin …

Traditionally, autoimmune pathogeneses have been attributed to CD4+ T lymphocytes, as in
multiple sclerosis (MS), rheumatoid arthritis, type 1 diabetes mellitus, and/or to B …

The central nervous system (CNS) is traditionally viewed as an immune privileged site in
which overzealous immune cells are prevented from doing irreparable damage. It was …

Multiple sclerosis is an inflammatory, demyelinating, central nervous system disease
mediated by myelin-specific T cells. Environmental triggers that cause the breakdown of …

The major known genetic risk factors in multiple sclerosis reside in the major
histocompatibility complex (MHC) region. Although there is strong evidence implicating …