Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

CD45 in human physiology and clinical medicine

A Rheinländer, B Schraven, U Bommhardt - Immunology letters, 2018 - Elsevier
CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively
expressed on all nucleated cells of the hematopoietic system. It is characterized by the …

[HTML][HTML] The therapeutic potential of galectin-3 inhibition in fibrotic disease

RJ Slack, R Mills, AC Mackinnon - … Journal of Biochemistry & Cell Biology, 2021 - Elsevier
Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member
galectin family that are evolutionarily highly conserved. It is the only chimeric protein with a …

Galectin expression in cancer diagnosis and prognosis: A systematic review

VL Thijssen, R Heusschen, J Caers… - Biochimica et Biophysica …, 2015 - Elsevier
Galectins are a family of proteins that bind to specific glycans thereby deciphering the
information captured within the glycome. In the last two decades, several galectin family …

Discovery and optimization of the first highly effective and orally available galectin-3 inhibitors for treatment of fibrotic disease

FR Zetterberg, A MacKinnon, T Brimert… - Journal of Medicinal …, 2022 - ACS Publications
Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases
such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a …

The structural biology of galectin-ligand recognition: current advances in modeling tools, protein engineering, and inhibitor design

CP Modenutti, JIB Capurro, S Di Lella… - Frontiers in Chemistry, 2019 - frontiersin.org
Galectins (formerly known as “S-type lectins”) are a subfamily of soluble proteins that
typically bind β-galactoside carbohydrates with high specificity. They are present in many …

The role of galectins as modulators of metabolism and inflammation

MF Brinchmann, DM Patel… - Mediators of …, 2018 - Wiley Online Library
Galectins are β‐galcotosid‐binding lectins. The function of galectins varies with their tissue‐
specific and subcellular location, and their binding to carbohydrates makes them key players …

Interplay between conformational entropy and solvation entropy in protein–ligand binding

ML Verteramo, O Stenstrom, MM Ignjatovic… - Journal of the …, 2019 - ACS Publications
Understanding the driving forces underlying molecular recognition is of fundamental
importance in chemistry and biology. The challenge is to unravel the binding …

Glycans in drug discovery

P Valverde, A Ardá, NC Reichardt… - …, 2019 - pubs.rsc.org
Glycans are key players in many biological processes. They are essential for protein folding
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …

A potential role for Galectin-3 inhibitors in the treatment of COVID-19

JL Caniglia, MR Guda, S Asuthkar, AJ Tsung… - PeerJ, 2020 - peerj.com
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the
causative agent of coronavirus disease 2019 (COVID-19), has been declared a global …