The classic view of sensorineural hearing loss has been that the primary damage targets are
hair cells and that auditory nerve loss is typically secondary to hair cell degeneration …

Atypical behavioral responses to environmental sounds are common in autistic children and
adults, with 50–70% of this population exhibiting decreased sound tolerance (DST) at some …

The noise-induced and age-related loss of synaptic connections between auditory-nerve
fibers and cochlear hair cells is well-established from histopathology in several mammalian …

Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to
the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that …

Spiral ganglion (SG) neurons of the cochlea convey all auditory inputs to the brain, yet the
cellular and molecular complexity necessary to decode the various acoustic features in the …

Tinnitus is a pervasive public health issue that affects∼ 15% of the United States population.
Similar estimates have also been shown on a global scale, with similar prevalence found in …

Functional molecular characterization of the cochlea has mainly been driven by the
deciphering of the genetic architecture of sensorineural deafness. As a result, the search for …

Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to
sounds). However, estimates of the association between hyperacusis and tinnitus is lacking …

Atg7 is an indispensable factor that plays a role in canonical nonselective autophagy. Here
we show that genetic ablation of Atg7 in outer hair cells (OHCs) in mice caused stereocilium …

Impairments of vision and hearing are highly prevalent conditions limiting the quality of life
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …