HIV-associated neurocognitive disorder

DB Clifford, BM Ances - The Lancet infectious diseases, 2013 - thelancet.com
Neurological involvement in HIV is often associated with cognitive impairment. Although
severe and progressive neurocognitive impairment has become rare in HIV clinics in the era …

The choroid plexus and its role in the pathogenesis of neurological infections

D Thompson, CA Brissette, JA Watt - Fluids and Barriers of the CNS, 2022 - Springer
The choroid plexus is situated at an anatomically and functionally important interface within
the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the …

Increased brain-predicted aging in treated HIV disease

JH Cole, J Underwood, MWA Caan, D De Francesco… - Neurology, 2017 - AAN Enterprises
Objective: To establish whether HIV disease is associated with abnormal levels of age-
related brain atrophy, by estimating apparent brain age using neuroimaging and exploring …

Assessment, diagnosis, and treatment of HIV-associated neurocognitive disorder: a consensus report of the mind exchange program

Mind Exchange Working Group… - Clinical Infectious …, 2013 - academic.oup.com
Many practical clinical questions regarding the management of human immunodeficiency
virus (HIV)–associated neurocognitive disorder (HAND) remain unanswered. We sought to …

Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis

DW Williams, EA Eugenin, TM Calderon… - Journal of leukocyte …, 2012 - academic.oup.com
ABSTRACT HIV continues to be a global health crisis with more than 34 million people
infected worldwide (UNAIDS: Report on the Global AIDS Epidemic 2010, Geneva, World …

Sphingolipid control of cognitive functions in health and disease

LS Kalinichenko, E Gulbins, J Kornhuber… - Progress in Lipid …, 2022 - Elsevier
Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …

Synaptic dysfunction in the hippocampus accompanies learning and memory deficits in human immunodeficiency virus type-1 Tat transgenic mice

S Fitting, BM Ignatowska-Jankowska, C Bull… - Biological …, 2013 - Elsevier
BACKGROUND: Human immunodeficiency virus (HIV) associated neurocognitive disorders
(HAND), including memory dysfunction, continue to be a major clinical manifestation of HIV …

Could antiretroviral neurotoxicity play a role in the pathogenesis of cognitive impairment in treated HIV disease?

J Underwood, KR Robertson, A Winston - Aids, 2015 - journals.lww.com
Whilst effective antiretroviral therapy is protective against the more severe forms of HIV-
associated brain disease, there remains a large burden of clinically symptomatic cognitive …

Neuroinflammation in HIV-associated depression: Evidence and future perspectives

A Mudra Rakshasa-Loots, HC Whalley, JH Vera… - Molecular …, 2022 - nature.com
People living with HIV face a high risk of mental illness, especially depression. We do not yet
know the precise neurobiological mechanisms underlying HIV-associated depression …

Poorer cognitive performance in perinatally HIV-infected children versus healthy socioeconomically matched controls

S Cohen, JA Ter Stege, GJ Geurtsen… - Clinical Infectious …, 2015 - academic.oup.com
Background. Despite the declining incidence of severe neurological complications such as
HIV encephalopathy, human immunodeficiency virus (HIV) infection in children is still …