Methylation is a universal biochemical process which covalently adds methyl groups to a
variety of molecular targets. It plays a critical role in two major global regulatory …

The preimplantation period of embryonic development can be a key window for
programming of postnatal development because extensive epigenetic remodeling occurs …

Purpose MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-
nucleotide polymorphisms that significantly reduce its activity, resulting in an increase in …

Individual analysis of the epigenome of preimplantation embryos is useful for characterizing
each embryo and for investigating the effects of environmental factors on their epigenome …

Epigenetic changes induced in the early developmental stages by the surrounding
environment can have not only short-term but also long-term consequences throughout life …

Epigenetic modifications established in the early developmental stages can have long‐term
consequences throughout life. This concept encompasses the possibility of controlling …

Methylation is a crucially important ubiquitous biochemical process: It relies on 2 cycles, the
folates and the one carbon cycles, which activity is affected by MTHFR SNPs (Methylene …

The enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) links the folate cycle that
produces one-carbon units with the methionine cycle that converts these into S …

Аннотация Актуальность: Обмен фолатов оказывает влияние на работу яичников,
процессы имплантации, эмбриогенез и общий ход беременности. Помимо известного …

Preeclampsia is a pregnancy complication arising from multiple etiologies, one of its causes
being abnormal placentation. Successful embryo implantation and development rely on …