Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than
half of all patients with cancer. In addition to the well-documented direct cytotoxic effects, RT …

Purpose Radiation-induced fibrosis (RIF) is a long-term side effect of external beam
radiation therapy for the treatment of cancer. It results in a multitude of symptoms that …

Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and
progressive disease with high mortality and limited therapeutic options. Excessive …

Recruitment of immune cells to the site of inflammation by the chemokine CCL1 is important
in the pathology of inflammatory diseases. Here, we examined the role of CCL1 in …

Purpose Ionizing radiation (IR)–induced pulmonary fibrosis (PF) is an irreversible and
severe late effect of thoracic radiation therapy. The goal of this study was to determine …

Fibrosis is a pathological process caused by abnormal wound healing response, which
often leads to excessive deposition of extracellular matrix, distortion of organ architecture …

Regenerative medicine using mesenchymal stem cells for the purposes of tissue repair has
garnered considerable public attention due to the potential of returning tissues and organs …

Chemokines are crucial autocrine and paracrine players in tumor development. In particular,
CXCL12, through its receptors CXCR4 and CXCR7, affects tumor progression by controlling …

Background: Radiotherapy is a mainstay for the treatment of lung cancer that can induce
pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor …

Abstract AMD3100 (plerixafor), a CXCR4 antagonist, has opened a variety of avenues for
potential therapeutic approaches in different refractory diseases. The CXCL12/CXCR4 axis …