Nanozyme-based strategies for efficient theranostics of brain diseases

R Xu, S Zhang, P Wang, R Zhang, P Lin, Y Wang… - Coordination Chemistry …, 2024 - Elsevier
Oxidative stress emerges as a critical mechanism underlying the development and
progression of various brain diseases, arising from either increased generation of reactive …

The therapeutic importance of acid-base balance

BN Quade, MD Parker, R Occhipinti - Biochemical pharmacology, 2021 - Elsevier
Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …

Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1

ML Jennings - American Journal of Physiology-Cell …, 2021 - journals.physiology.org
The major transmembrane protein of the red blood cell, known as band 3, AE1, and
SLC4A1, has two main functions: 1) catalysis of Cl−/HC O 3− exchange, one of the steps in …

[HTML][HTML] Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2 …

S Lee, NJ Toft, TV Axelsen, MS Espejo… - Breast Cancer …, 2023 - Springer
Background Carbonic anhydrases catalyze CO2/HCO3–buffer reactions with implications for
effective H+ mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated …

[HTML][HTML] Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism

CT Supuran - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
While the carbonic anhydrase (CA, EC 4.2. 1.1) superfamily of enzymes has been described
primarily as involved only in pH regulation for decades, it also has many other important …

Carbon dioxide transport across membranes

M Michenkova, S Taki, MC Blosser… - Interface …, 2021 - royalsocietypublishing.org
Carbon dioxide (CO2) movement across cellular membranes is passive and governed by
Fick's law of diffusion. Until recently, we believed that gases cross biological membranes …

Development of human carbonic anhydrase II heterobifunctional degraders

CB O'Herin, YW Moriuchi, TA Bemis… - Journal of medicinal …, 2023 - ACS Publications
Human carbonic anhydrase II (hCAII) is a metalloenzyme essential to critical physiological
processes in the body. hCA inhibitors are used clinically for the treatment of indications …

[HTML][HTML] Carbon dioxide and MAPK signalling: towards therapy for inflammation

H Gałgańska, W Jarmuszkiewicz… - Cell Communication and …, 2023 - Springer
Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …

Calcification in the coralline red algae: a synthesis

SJ McCoy, CM Pueschel, CE Cornwall, S Comeau… - …, 2023 - Taylor & Francis
ABSTRACT A descriptive model of calcification in the coralline red algae is integral to
understanding their contributions to marine geochemistry, the responses of seascapes to …

Biomedical applications of prokaryotic carbonic anhydrases: an update

C Capasso, CT Supuran - Expert Opinion on Therapeutic Patents, 2024 - Taylor & Francis
Introduction This review offers an updated perspective on the biomedical applications of
prokaryotic carbonic anhydrases (CAs), emphasizing their potential as targets for drug …