HDL-based therapeutics: A promising frontier in combating viral and bacterial infections

A Rani, JT Stadler, G Marsche - Pharmacology & Therapeutics, 2024 - Elsevier
Low levels of high-density lipoprotein (HDL) and impaired HDL functionality have been
consistently associated with increased susceptibility to infection and its serious …

[HTML][HTML] Neuroinflammation in Alzheimer's Disease: A Potential Role of Nose-Picking in Pathogen Entry via the Olfactory System?

X Zhou, P Kumar, DJ Bhuyan, SO Jensen, TL Roberts… - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by
progressive cognitive decline and memory impairment. Many possible factors might …

Dual-mode fluorescence and electrochemiluminescence sensors based on Ru-MOF nanosheets for sensitive detection of apoE genes

H Hu, H Cui, X Yin, Q Fan, H Shuai, J Zhang… - Journal of Materials …, 2024 - pubs.rsc.org
A fluorescence–electrochemiluminescence (FL–ECL) dual-mode sensor for apoE gene
detection has been developed, leveraging the unique properties of ruthenium metal organic …

[HTML][HTML] Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD

S Ukraintseva, AP Yashkin, I Akushevich… - Experimental …, 2024 - Elsevier
Introduction Diverse pathogens (viral, bacterial, fungal) have been associated with
Alzheimer's disease (AD) and related traits in various studies. This suggests that …

Perturbed Lipid Metabolism Transduction Pathways in SARS-CoV-2 Infection and Their Possible Treating Nutraceuticals

A Shukla, A Singh, S Tripathi - Journal of the American Nutrition …, 2024 - Taylor & Francis
Abstract The coronavirus disease 2019 (COVID-19) epidemic has evolved into an
international public health concern. Its causing agent was SARS-CoV-2 (severe acute …

Prior infections are associated with smaller hippocampal volume in older women

VA Popov, S Ukraintseva, H Duan, KG Arbeev… - Frontiers in …, 2024 - frontiersin.org
Accumulating evidence suggests that infections may play a major role in Alzheimer's
disease (AD), however, mechanism is unclear, as multiple pathways may be involved. One …

No clear evidence for relationships of Apolipoprotein E genotype with measures of common infections in three UK cohorts

RE Green, A Fernandez-Sanles, C Felici… - medRxiv, 2024 - medrxiv.org
APOE genotype is the strongest genetic risk factor for late onset Alzheimer's disease, with
the ϵ2 and ϵ4 alleles decreasing and increasing risk relative to the ϵ3 allele, respectively …

APOE AS A RISK FACTOR FOR ALZHEIMER'S DISEASE AND LIPID METABOLISM DISORDERS: MOLECULAR ANALYSIS

E Kowalska, Ł Madej, K Szafraniec, J Rachuna - Health Problems of … - termedia.pl
The gene encoding apolipoprotein E (APOE) plays a key role in many biological processes,
including lipid metabolism, brain homeostasis, and functioning of the circulatory system …