ABSTRACT Children with Hutchinson–Gilford progeria syndrome (HGPS) succumb to
myocardial infarction and stroke in their teen years. Endothelial dysfunction is an early event …

Abstract Background Bisphosphonates (BPs) are pyrophosphate analogues widely used in
diseases related to bone loss and increased bone turnover. Their high affinity for bone …

Progeria is a globally noticed rare genetic disorder manifested by premature aging with no
effective treatment. Under these circumstances, farnesyltransferase inhibitors (FTIs) are …

As human longevity increases, understanding the molecular mechanisms that drive aging
becomes ever more critical to promote health and prevent age-related disorders. Premature …

Hutchinson–Gilford progeria syndrome (HGPS, progeria) is a rare genetic disease
characterized by premature aging and death in childhood for which there were no approved …

Hutchinson–Gilford progeria syndrome (HGPS) is a lethal premature aging that recapitulates
many normal aging characteristics. This disorder is caused by mutation in the LMNA gene …

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder caused
by the mutant protein progerin, which is expressed by the abnormal splicing of the LMNA …

In the last decade, we have seen increasing evidence of the importance of structural nuclear
proteins such as lamins in nuclear architecture and compartmentalization of genome …

Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) and progeroid
laminopathies (PL) are extremely rare genetic diseases with extremely poor prognoses. This …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition associated with
mutations in the LMNA gene. This disease recapitulates some aspects of normal aging, such …