Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition associated with
mutations in the LMNA gene. This disease recapitulates some aspects of normal aging, such …

Highlights•A-type lamins (LMNA gene) play important structural and regulatory
roles.•Multiple diseases arise from LMNA mutations, including progeroid …

What if the next generation of successful treatments was hidden in the current
pharmacopoeia? Identifying new indications for existing drugs, also called the drug …

Blood vessel chips are bioengineered microdevices, consisting of biomaterials, human cells,
and microstructures, which recapitulate essential vascular structure and physiology and …

Ras proteins have been reported to play key role in oncologic diseases. Ras proteins are
associated with cellular membranes for its carcinogenic activities through post-translational …

Protein farnesylation is a post-translational modification where a 15-carbon farnesyl
isoprenoid is appended to the C-terminal end of a protein by farnesyltransferase (FTase) …

Introduction Hyperphosphorylated Tau formed neurofibrillary tangles was one of the major
neuropathological hallmarks of Alzheimer's disease (AD). Dysfunctional insulin signaling in …

Mutations in LMNA, encoding A-type lamins, are responsible for laminopathies including
muscular dystrophies, lipodystrophies, and premature ageing syndromes. LMNA mutations …

Hutchinson–Gilford progeria syndrome (HGPS) is a uniformly fatal condition that is
especially prevalent in skin, cardiovascular, and musculoskeletal systems. A wide gap exists …

Since ancient times aging has also been regarded as a disease, and humankind has always
strived to extend the natural lifespan. Analyzing the genes involved in aging and disease …