Polyglutamine (polyQ) diseases are a family of neurodegenerative disorders with very
heterogeneous clinical presentations, although with common features such as progressive …

Ex situ bioengineering is one of the most promising perspectives in the field of regenerative
medicine allowing for organ reconstruction outside the living body; ie on the laboratory …

The subpallium comprises large parts of the basal ganglia including striatum and globus
pallidus. Genes and factors involved in the development of the subpallium have been …

Huntington's disease is currently incurable, but cell therapy is seen as a promising
alternative treatment. We analyze the safety and efficacy of the intrastriatal transplantation of …

Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised
certain expectations in the past decade as an effective cell-based-therapy for this …

The neuromate is a commercially available, image-guided robotic system for use in
stereotactic surgery and is employed in Europe and North America. In June 2015, this …

Intra-striatal transplantation of homotypic fetal tissue at the time of peak striatal neurogenesis
can provide some functional benefit to patients suffering from Huntington's disease …

Huntington's disease (HD) is a devastating, fatal, autosomal dominant condition in which the
abnormal gene codes for a mutant form of huntingtin that causes widespread neuronal …

Neurodegenerative movement disorders, such as Huntington's disease (HD), share a
progressive and relentless course with increasing motor disability, linked with …

Neurological diseases with genetic etiologies result in the loss or dysfunction of neural cells
throughout the CNS. At present, few treatment options exist for the majority of neurogenetic …