Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come

P Yingchoncharoen, DS Kalinowski… - Pharmacological …, 2016 - ASPET
Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: a review

M Kanamala, WR Wilson, M Yang, BD Palmer, Z Wu - Biomaterials, 2016 - Elsevier
As the mainstay in the treatment of various cancers, chemotherapy plays a vital role, but still
faces many challenges, such as poor tumour selectivity and multidrug resistance (MDR) …

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

PL Felgner, TR Gadek, M Holm… - Proceedings of the …, 1987 - National Acad Sciences
A DNA-transfection protocol has been developed that makes use of a synthetic cationic lipid,
N-[1-(2, 3-dioleyloxy) propyl]-N, N, N-trimethylammonium chloride (DOTMA). Small …

The emerging field of lipidomics

MR Wenk - Nature reviews Drug discovery, 2005 - nature.com
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large
number of genetic studies and by many human diseases that involve the disruption of lipid …

Multistimuli-responsive supramolecular vesicles based on water-soluble pillar [6] arene and SAINT complexation for controllable drug release

Y Cao, XY Hu, Y Li, X Zou, S Xiong, C Lin… - Journal of the …, 2014 - ACS Publications
Supramolecular binary vesicles based on the host–guest complexation of water-soluble
pillar [6] arene (WP6) and SAINT molecule have been successfully constructed, which …

Structure of the inverted hexagonal (HII) phase, and non-lamellar phase transitions of lipids

JM Seddon - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1990 - Elsevier
IV Thermodynarmcs of non-lamellar phase transitions A Lipid self-assembly and the
hydrophoblc effect B Intermolecular Interactions C Interfaclal curvature D Lateral expansion …

Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release

TL Andresen, SS Jensen, K Jørgensen - Progress in lipid research, 2005 - Elsevier
Tumor specific drug delivery has become increasingly interesting in cancer therapy, as the
use of chemotherapeutics is often limited due to severe side effects. Conventional drug …

On the formulation of pH-sensitive liposomes with long circulation times

S Simões, JN Moreira, C Fonseca, N Düzgüneş… - Advanced drug delivery …, 2004 - Elsevier
Strategies used to enhance liposome-mediated drug delivery in vivo include the
enhancement of stability and circulation time in the bloodstream, targeting to specific tissues …

A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery

SR Paliwal, R Paliwal, SP Vyas - Drug delivery, 2015 - Taylor & Francis
The pH-sensitive liposomes have been extensively used as an alternative to conventional
liposomes in effective intracellular delivery of therapeutics/antigen/DNA/diagnostics to …

[图书][B] The structure of biological membranes

PL Yeagle - 2004 - taylorfrancis.com
Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …