Phosphodiesterases: Evolving Concepts and Implications for Human Therapeutics
Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides.
While the 11 PDE subfamilies share common features, key differences confer signaling …
While the 11 PDE subfamilies share common features, key differences confer signaling …
Personalised medicine in juvenile dermatomyositis: From novel insights in disease mechanisms to changes in clinical practice
SR Veldkamp, F van Wijk, A van Royen-Kerkhof… - Best Practice & …, 2024 - Elsevier
Juvenile dermatomyositis is characterized by childhood-onset chronic inflammation of the
muscles and skin, with potential involvement of other organs. Patients are at risk for long …
muscles and skin, with potential involvement of other organs. Patients are at risk for long …
[HTML][HTML] Spatial Transcriptomic Profiling of Human Saphenous Vein Exposed to Ex Vivo Arterial Haemodynamics—Implications for Coronary Artery Bypass Graft …
LW McQueen, SS Ladak, GR Layton… - International Journal of …, 2024 - mdpi.com
Vein graft disease is the process by which saphenous vein grafts, utilised for
revascularisation during coronary artery bypass graft surgery, undergo an inflammation …
revascularisation during coronary artery bypass graft surgery, undergo an inflammation …
Effects on Lipid Profile after One Year of Apremilast Therapy in Patients with Psoriasis: A Monocentric Experience
P Guerra, A Di Cesare, E Rosi, I Scandagli, G Silvi… - Life, 2024 - mdpi.com
Apremilast, a phosphodiesterase-4 inhibitor, has shown promise to have a potential
beneficial metabolic effect. We conducted a single-centre retrospective study on adult …
beneficial metabolic effect. We conducted a single-centre retrospective study on adult …