The overall success of human reproduction, either spontaneously or after IVF, is highly
dependent upon maternal age. The main reasons for age-related infertility include reduced …

It is well known that maternal ageing not only causes increased spontaneous abortion and
reduced fertility, but it is also a high genetic disease risk. Although assisted reproductive …

Oocyte quality is a critical factor limiting the efficiency of assisted reproductive technologies
(ART) and pregnancy success in farm animals and humans. ART success is diminished with …

A societal preference of delaying maternal age at first childbirth has increased reliance on
assisted reproductive technologies/therapies (ART) to conceive a child. Oocytes that have …

Neuropathic pain is associated with hyperexcitability and intrinsic firing of dorsal root
ganglia (DRG) neurons. These phenotypical changes can be long lasting, potentially …

An age-dependent increase in ribosomal DNA (rDNA) methylation has been observed
across a broad spectrum of somatic tissues and the male mammalian germline. Bisulfite …

It is well established that the decline in female reproductive outcomes is related to
postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is …

Methotrexate (MTX), an antifolate drug, is widely used for clinical treatment of malignancies
and ectopic pregnancy. Many studies have documented that MTX has strong side-effects on …

The mechanism of senescence is very complicated and can involve formation of
chromosome abnormalities and a decline in female fertility. In this study, 3-D visualization of …

Premature aging disorders provide the ideal model systems in understanding the process of
physiological aging. A spectrum of intersecting pathways plays crucial roles in the …