Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of
nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic …

Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly
evolving. We seek to provide a summary of recent findings in the field, with an emphasis to …

Oxidative stress inflicts mitochondrial dysfunction, which has been recognized as a key
driver of intestinal diseases. Resveratrol (RSV) and its derivative pterostilbene (PTS) are …

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

Neurodegenerative disorders include different neurological conditions that affect nerve cells,
causing the progressive loss of their functions and ultimately leading to loss of mobility …

L-lactate plays a critical role in learning and memory. Studies in rats showed that
administration of exogenous L-lactate into the anterior cingulate cortex and hippocampus …

Astrocyte-derived L-lactate was shown to confer beneficial effects on synaptic plasticity and
cognitive functions. However, how astrocytic G i signaling in the anterior cingulate cortex …

Abstract Sirtuins (SIRT1-SIRT7), a family of nicotinamide adenine dinucleotide (NAD+)-
dependent enzymes, are key regulators of life span and metabolism. In addition to acting as …

One of the major environmental factors that induce PD is Manganese (Mn). Cellular and
molecular mechanism of parkinsonism caused by Mn has not been explored clearly. The …

Heavy metals are often found in soil and can contaminate drinking water, posing a serious
threat to human health. Molecular pathways and curation therapies for mitigating heavy …