[HTML][HTML] NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …
identified in the membrane of phagocytic cells. For many years, its only known role was in …
[HTML][HTML] Neutrophils: between host defence, immune modulation, and tissue injury
P Kruger, M Saffarzadeh, ANR Weber, N Rieber… - PLoS …, 2015 - journals.plos.org
Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …
Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …
[HTML][HTML] Structure of the core human NADPH oxidase NOX2
NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces
superoxide (O2•−), a key reactive oxygen species (ROS) that is essential in innate and …
superoxide (O2•−), a key reactive oxygen species (ROS) that is essential in innate and …
[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits
SA Belambri, L Rolas, H Raad… - European journal of …, 2018 - Wiley Online Library
Neutrophils are key cells of innate immunity and during inflammation. Upon activation, they
produce large amounts of superoxide anion (O2−.) and ensuing reactive oxygen species …
produce large amounts of superoxide anion (O2−.) and ensuing reactive oxygen species …
[HTML][HTML] Selective activation of PFKL suppresses the phagocytic oxidative burst
In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the
pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen …
pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen …
Common severe infections in chronic granulomatous disease
BE Marciano, C Spalding, A Fitzgerald… - Clinical Infectious …, 2015 - academic.oup.com
Background. Chronic granulomatous disease (CGD) is due to defective nicotinamide
adenine dinucleotide phosphate oxidase activity and characterized by recurrent infections …
adenine dinucleotide phosphate oxidase activity and characterized by recurrent infections …
Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system
B Lassègue, A San Martín, KK Griendling - Circulation research, 2012 - Am Heart Assoc
atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …
Inherited and acquired immunodeficiencies underlying tuberculosis in childhood
S Boisson‐Dupuis, J Bustamante… - Immunological …, 2015 - Wiley Online Library
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb) and a few related
mycobacteria, is a devastating disease, killing more than a million individuals per year …
mycobacteria, is a devastating disease, killing more than a million individuals per year …