Cardiovascular diseases (CVDs) are one of the leading causes of the most considerable
mortality globally, and it has been tried to find the molecular mechanisms and design new …

Oxidized LDLs (oxLDLs) and oxysterols play a key role in endothelial dysfunction and the
development of atherosclerosis. The loss of vascular endothelium function negatively …

Patients with chronic inflammatory disorders such as rheumatoid arthritis (RA) have a high
risk of developing cardiovascular disease. We evaluated the effects of TNF-α and IL-6 on …

Objective Innate immune protein C1q plays a dual role in the chronic inflammatory disease
of atherosclerosis. Complement activation via C1q exacerbates pathology in the …

The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for
binding and uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells. LOX-1 is …

Patients with chronic kidney disease (CKD) are at increased risk of atherosclerotic
cardiovascular disease and loss of renal parenchyma accelerates atherosclerosis in animal …

Obesity is related to an increased risk of developing prostate cancer with high malignancy
stages or metastasis. Recent results demonstrated that LOX-1, a receptor associated with …

Hypertension remains the leading preventable risk factor for stroke and coronary artery
disease, significantly contributing to all-cause global mortality and predisposing patients to …

Matrix metalloproteinase-9 (MMP-9), one of the most investigated and studied biomarkers of
the MMPs family, is a zinc-dependent proteolytic metalloenzyme whose primary function is …

Abstract Cilostazol (Ciloz) a potent Type III phosphodiesterase inhibitor is effective against
inflammation, insulin resistance and cardiomyopathy. However, the effect of Ciloz on obesity …