Neuroscience of apathy and anhedonia: a transdiagnostic approach

M Husain, JP Roiser - Nature Reviews Neuroscience, 2018 - nature.com
Apathy and anhedonia are common syndromes of motivation that are associated with a wide
range of brain disorders and have no established therapies. Research using animal models …

Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies

D Tromp, A Dufour, S Lithfous, T Pebayle… - Ageing research …, 2015 - Elsevier
Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

[HTML][HTML] Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota

Y Wang, Q Tong, SR Ma, ZX Zhao, LB Pan… - Signal transduction and …, 2021 - nature.com
The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In
this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine …

States of curiosity modulate hippocampus-dependent learning via the dopaminergic circuit

MJ Gruber, BD Gelman, C Ranganath - Neuron, 2014 - cell.com
People find it easier to learn about topics that interest them, but little is known about the
mechanisms by which intrinsic motivational states affect learning. We used functional …

Human cognitive aging: Corriger la fortune?

U Lindenberger - science, 2014 - science.org
Human cognitive aging differs between and is malleable within individuals. In the absence
of a strong genetic program, it is open to a host of hazards, such as vascular conditions …

Measuring macroscopic brain connections in vivo

S Jbabdi, SN Sotiropoulos, SN Haber… - Nature …, 2015 - nature.com
Decades of detailed anatomical tracer studies in non-human animals point to a rich and
complex organization of long-range white matter connections in the brain. State-of-the art in …

Building connectomes using diffusion MRI: why, how and but

SN Sotiropoulos, A Zalesky - NMR in Biomedicine, 2019 - Wiley Online Library
Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How
do different image acquisition parameters, fiber tracking algorithms and other …

Decision making in the ageing brain: changes in affective and motivational circuits

GR Samanez-Larkin, B Knutson - Nature Reviews Neuroscience, 2015 - nature.com
As the global population ages, older decision makers will be required to take greater
responsibility for their own physical, psychological and financial well-being. With this in …

The affective neuroscience of aging

M Mather - Annual review of psychology, 2016 - annualreviews.org
Although aging is associated with clear declines in physical and cognitive processes,
emotional functioning fares relatively well. Consistent with this behavioral profile, two core …

[HTML][HTML] Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis

QJM Huys, DA Pizzagalli… - … of mood & …, 2013 - biolmoodanxietydisord …
Depression is characterised partly by blunted reactions to reward. However, tasks probing
this deficiency have not distinguished insensitivity to reward from insensitivity to the …