Management of the patient with sepsis comprises three key branches: control of the
underlying infection, haemodynamic stabilization, and modulation of the host response …

Sepsis is a common consequence of infection, associated with a mortality rate> 25%.
Although community-acquired sepsis is more common, hospital-acquired infection is more …

Background Timely administration of antibiotics is one of the most important interventions in
reducing mortality in sepsis. However, administering antibiotics within a strict time threshold …

Coagulase-negative staphylococci (CoNS) are among the most frequently recovered
bacteria in routine clinical care. Their incidence has steadily increased over the past …

Background Influential studies conclude that each hour until antibiotics increases mortality in
sepsis. However, these analyses often (1) adjusted for limited covariates,(2) included …

Abstract The Centers for Medicare & Medicaid Services (CMS) introduced the Severe
Sepsis/Septic Shock Management Bundle (SEP-1) as a pay-for-reporting measure in 2015 …

Introduction Sepsis is a life-threatening condition, and biomarkers are needed to diagnose
sepsis fast and accurately. We aimed to perform this meta-analysis to investigate the …

Importance It is unclear whether antimicrobial timing for sepsis has changed outside of
performance incentive initiatives. Objective To examine temporal trends and variation in time …

Distinguishing between bacterial and nonbacterial sources of fever and sepsis is
challenging in the acute setting. Rapid administration of effective antimicrobial drugs is one …

To investigate the bacterial epidemiology of blood cultures taken during the treatment of
critically ill burn patients, the use of antibiotics at admission and before the observation of …