Sex hormone signaling and regulation of immune function
Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine
antigens, differ between males and females. The quest to uncover the mechanisms for …
antigens, differ between males and females. The quest to uncover the mechanisms for …
[HTML][HTML] Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions
MJ Bunders, M Altfeld - Immunity, 2020 - cell.com
Men present more frequently with severe manifestations of coronavirus disease 2019
(COVID-19) and are at higher risk for death. The underlying mechanisms for these …
(COVID-19) and are at higher risk for death. The underlying mechanisms for these …
Estimates and projections of COVID-19 and parental death in the US
Methods| We estimated the expected number of affected children for each COVID-19 death
(the parental bereavement multiplier), allowing us to track parental bereavement as the …
(the parental bereavement multiplier), allowing us to track parental bereavement as the …
IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice
Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …
specific pain signaling is not well studied. Here we report that administration of IL-23 …
[HTML][HTML] MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
Antigenic stimulation promotes T cell metabolic reprogramming to meet increased
biosynthetic, bioenergetic, and signaling demands. We show that the one-carbon (1C) …
biosynthetic, bioenergetic, and signaling demands. We show that the one-carbon (1C) …
Worse progression of COVID‐19 in men: is testosterone a key factor?
VA Giagulli, E Guastamacchia, T Magrone, E Jirillo… - …, 2021 - Wiley Online Library
Background The novel severe acute respiratory syndrome coronavirus (SARS‐CoV‐2)
disease 2019 (COVID‐19) seems to have a worse clinical course among infected men …
disease 2019 (COVID‐19) seems to have a worse clinical course among infected men …
Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation
VD Gandhi, JY Cephus, AE Norlander… - The Journal of …, 2022 - Am Soc Clin Investig
Women have higher prevalence of asthma compared with men. In asthma, allergic airway
inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and …
inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and …
Sex steroid hormones and asthma in a nationwide study of US adults
Rationale: Women have a higher burden of asthma than men. Although sex hormones may
explain sex differences in asthma, their role is unclear. Objectives: To examine sex hormone …
explain sex differences in asthma, their role is unclear. Objectives: To examine sex hormone …
Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19?
RSR Kalidhindi, NA Borkar… - … of Physiology-Lung …, 2020 - journals.physiology.org
The incidence, severity, and mortality of ongoing coronavirus infectious disease 19 (COVID-
19) is greater in men compared with women, but the underlying factors contributing to this …
19) is greater in men compared with women, but the underlying factors contributing to this …
The roles of sex hormones in the course of atopic dermatitis
N Kanda, T Hoashi, H Saeki - International journal of molecular sciences, 2019 - mdpi.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by T helper 2 cell
(Th2)-shifted abnormal immunity, skin barrier impairment, and pruritus. The prevalence of …
(Th2)-shifted abnormal immunity, skin barrier impairment, and pruritus. The prevalence of …