The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …
A review on computer‐aided chemogenomics and drug repositioning for rational COVID‐19 drug discovery
S Maghsoudi, B Taghavi Shahraki… - Chemical Biology & …, 2022 - Wiley Online Library
Application of materials capable of energy harvesting to increase the efficiency and
environmental adaptability is sometimes reflected in the ability of discovery of some traces in …
environmental adaptability is sometimes reflected in the ability of discovery of some traces in …
Pharmacogenetics and precision medicine approaches for the improvement of COVID-19 therapies
M Biswas, N Sawajan, T Rungrotmongkol… - Frontiers in …, 2022 - frontiersin.org
Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19)
pandemic situations without establishing clinical effectiveness or tailoring safety. A …
pandemic situations without establishing clinical effectiveness or tailoring safety. A …
Advancing precision medicine: A review of innovative In Silico approaches for drug development, clinical pharmacology and personalized healthcare
L Marques, B Costa, M Pereira, A Silva, J Santos… - Pharmaceutics, 2024 - mdpi.com
The landscape of medical treatments is undergoing a transformative shift. Precision
medicine has ushered in a revolutionary era in healthcare by individualizing diagnostics and …
medicine has ushered in a revolutionary era in healthcare by individualizing diagnostics and …
Could histamine H1 receptor antagonists be used for treating COVID-19?
C Qu, GM Fuhler, Y Pan - International Journal of Molecular Sciences, 2021 - mdpi.com
COVID-19 has rapidly become a pandemic worldwide, causing extensive and long-term
health issues. There is an urgent need to identify therapies that limit SARS-CoV-2 infection …
health issues. There is an urgent need to identify therapies that limit SARS-CoV-2 infection …
Molecular mechanisms related to responses to oxidative stress and antioxidative therapies in COVID-19: a systematic review
The coronavirus disease (COVID-19) pandemic is a leading global health and economic
challenge. What defines the disease's progression is not entirely understood, but there are …
challenge. What defines the disease's progression is not entirely understood, but there are …
Bacterial and fungal co-infections and superinfections in a cohort of COVID-19 patients: real-life data from an Italian third level hospital
M Ceccarelli, A Marino, S Pulvirenti, V Coco… - Infectious Disease …, 2022 - mdpi.com
The use of immune suppressive drugs combined with the natural immune suppression
caused by SARS-CoV-2 can lead to a surge of secondary bacterial and fungal infections …
caused by SARS-CoV-2 can lead to a surge of secondary bacterial and fungal infections …
Role of cytochrome P450 2C9 in COVID-19 treatment: current status and future directions
The major human liver drug metabolising cytochrome P450 (CYP) enzymes are
downregulated during inflammation and infectious disease state, especially during …
downregulated during inflammation and infectious disease state, especially during …
Repurposing of drugs targeting the cytokine storm induced by SARS‐CoV‐2
WH Ng, PCH Tang, S Mahalingam… - British Journal of …, 2023 - Wiley Online Library
A cytokine storm is one of the leading causes of acute respiratory distress syndrome (ARDS)
and sepsis‐associated multiple organ failure in many respiratory viral infections, including …
and sepsis‐associated multiple organ failure in many respiratory viral infections, including …
In vitro evaluation of the impact of Covid-19 therapeutic agents on the hydrolysis of the antiviral prodrug remdesivir
Q Zhang, PW Melchert, JS Markowitz - Chemico-Biological Interactions, 2022 - Elsevier
Abstract Remdesivir (RDV, Veklury®) is an FDA-approved prodrug for the treatment of
hospitalized patients with COVID-19. Recent in vitro studies have indicated that human …
hospitalized patients with COVID-19. Recent in vitro studies have indicated that human …