Opiate and cocaine addictions are major social and medical problems that impose a
significant burden on society. Despite the size and scope of these problems, there are few …

Pérdida de recompensa como dolor psicológico. Este artículo resume una serie de trabajos
que sugieren un paralelo entre los mecanismos del dolor físico y el miedo, y los que …

Pain is a complex human trait. It is likely that the interaction of multiple genes, each with a
small individual effect, along with the effect of environmental factors, influences the clinical …

The kappa opioid receptor (KOR) plays a role in stress responsivity, opiate withdrawal and
responses to cocaine. KOR activation by its endogenous ligand dynorphin A (1-17) …

A genome-wide association study was conducted using microarray technology to identify
genes that may be associated with the vulnerability to develop heroin addiction, using DNA …

The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled
receptors as they can be coupled to its mating pathway. However, some receptors, including …

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with population
prevalence of approximately 60–70 per 10,000. Data shows that both opioid system function …

It is generally assumed that combinations of polymorphic alleles of different genes contribute
to polygenetic disorders. Variants of the opioid receptors are the obvious candidates …

Three experiments explored the role of the opioid system in consummatory successive
negative contrast. In Experiment 1, rats treated with the nonspecific opioid-receptor …

Objective: The completion of the human genome sequence has spurred investigation of the
genetic contribution to substance dependence. In this article some of the recent scientific …