[HTML][HTML] Role of gut microbiota in neurological disorders and its therapeutic significance

P Tiwari, R Dwivedi, M Bansal, M Tripathi… - Journal of Clinical …, 2023 - mdpi.com
In humans, the gut microbiota (GM) are known to play a significant role in the metabolism of
nutrients and drugs, immunomodulation, and pathogen defense by inhabiting the …

[HTML][HTML] Biomarkers associated with the pathogenesis of Alzheimer's disease

H Wang, M Sun, W Li, X Liu, M Zhu… - Frontiers in Cellular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a progressive degenerative neurological illness with insidious
onset. Due to the complexity of the pathogenesis of AD and different pathological changes …

[HTML][HTML] Oxygen metabolism abnormality and Alzheimer's disease: An update

G Liu, C Yang, X Wang, X Chen, Y Wang, W Le - Redox Biology, 2023 - Elsevier
Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …

Microbiota from Exercise Mice Counteracts High‐Fat High‐Cholesterol Diet‐Induced Cognitive Impairment in C57BL/6 Mice

R Li, R Liu, L Chen, G Wang, L Qin… - … Medicine and Cellular …, 2023 - Wiley Online Library
Gut microbes may be the critical mediators for the cognitive enhancing effects of exercise.
Via fecal microbiota transplantation (FMT), this study is aimed at determining the mechanism …

Inhibition of VDAC1 Rescues Aβ1-42‐Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/β‐Catenin Pathways

X Zhou, X Tang, T Li, D Li, Z Gong… - Mediators of …, 2023 - Wiley Online Library
Beta‐amyloid (Aβ) accumulation in the brains of Alzheimer's disease (AD) patients leads to
mitochondrial dysfunction and ferroptosis in neurons. Voltage‐dependent anion channel 1 …

Conjugated linoleic acid downregulates Alzheimer's hallmarks in aluminum mouse model through an Nrf2-mediated adaptive response and increases brain glucose …

R Cuciniello, D Luongo, A Ferramosca, P Lunetti… - Free Radical Biology …, 2022 - Elsevier
Mitochondrial dysfunction, oxidative stress, inflammation and glucose dysmetabolism are
pathological signs of Alzheimer's disease (AD). Dietary aluminum (Al) overload is often used …

[HTML][HTML] TRP channels: role in neurodegenerative diseases and therapeutic targets

MA Rather, A Khan, L Wang, S Jahan, MU Rehman… - Heliyon, 2023 - cell.com
TRP (Transient receptor potential) channels are integral membrane proteins consisting of a
superfamily of cation channels that allow permeability of both monovalent and divalent …

Unveiling the Interplay of AMPK/SIRT1/PGC-1α axis in Brain Health: Promising Targets Against Aging and NDDs

PS Rakshe, BJ Dutta, S Chib, N Maurya… - Ageing Research Reviews, 2024 - Elsevier
The escalating prevalence of neurodegenerative diseases (NDDs) within an aging global
population presents a pressing challenge. The multifaceted pathophysiological mechanisms …

Tanshinone-IIA mediated neuroprotection by modulating neuronal pathways

K Sherawat, S Mehan - Naunyn-Schmiedeberg's Archives of …, 2023 - Springer
The progression of neurological diseases is mainly attributed to oxidative stress, apoptosis,
inflammation, and trauma, making them a primary public concern. Since no drugs can stop …

[HTML][HTML] Insight into oncogenic viral pathways as drivers of viral cancers: implication for effective therapy

AME Elkhalifa, SU Nabi, OS Shah, SM Bashir… - Current …, 2023 - mdpi.com
As per a recent study conducted by the WHO, 15.4% of all cancers are caused by infectious
agents of various categories, and more than 10% of them are attributed to viruses. The …