Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the
treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind …

This review covers the main aspects concerning the chemistry, the biological activity and the
analytical determination of oxazolidinones, the only new class of synthetic antibiotics …

One of the major impediments to drug development is low aqueous solubility and thus poor
bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the …

The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

The prodrug approach has emerged as a promising solution to combat bacterial resistance
and enhance treatment efficacy against bacterial infections. Here, we report an adenosine …

The emergence of bacterial resistance has motivated researchers to discover new
antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential …

Cathepsin B (CTSB), a lysosomal cysteine protease, plays an important role in human
physiology and pathology. CTSB is associated with various human diseases, and its …

Extensive research into prodrug modification of active pharmaceutical ingredients and
nanoparticle drug delivery systems has led to unprecedented levels of control over the …

Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …