Metabolic and signaling roles of ketone bodies in health and disease

P Puchalska, PA Crawford - Annual review of nutrition, 2021 - annualreviews.org
Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …

[HTML][HTML] Mitochondrial alterations in fatty liver diseases

B Fromenty, M Roden - Journal of hepatology, 2023 - Elsevier
Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

[HTML][HTML] Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial

M Ezpeleta, K Gabel, S Cienfuegos, F Kalam, S Lin… - Cell metabolism, 2023 - cell.com
Innovative non-pharmacological lifestyle strategies to treat non-alcoholic fatty liver disease
(NAFLD) are critically needed. This study compared the effects of alternate day fasting (ADF) …

Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD

MP Moore, RP Cunningham, GM Meers… - …, 2022 - Wiley Online Library
Background and Aims NAFLD and its more‐advanced form, steatohepatitis (NASH), is
associated with obesity and is an independent risk factor for cardiovascular, liver‐related …

[HTML][HTML] Metabolic drivers of non-alcoholic fatty liver disease

KK Bence, MJ Birnbaum - Molecular metabolism, 2021 - Elsevier
Background The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing
worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver …

Ins and outs of the TCA cycle: the central role of anaplerosis

M Inigo, S Deja, SC Burgess - Annual review of nutrition, 2021 - annualreviews.org
The reactions of the tricarboxylic acid (TCA) cycle allow the controlled combustion of fat and
carbohydrate. In principle, TCA cycle intermediates are regenerated on every turn and can …

Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in nonalcoholic fatty liver disease

V Azzu, M Vacca, S Virtue, M Allison, A Vidal-Puig - Gastroenterology, 2020 - Elsevier
Adipose tissue and the liver play significant roles in the regulation of whole-body energy
homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient …

[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD). Mitochondria as players and targets of therapies?

A Di Ciaula, S Passarella, H Shanmugam… - International Journal of …, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

[HTML][HTML] Emerging role of hepatic ketogenesis in fatty liver disease

RGR Mooli, SK Ramakrishnan - Frontiers in Physiology, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …

A fad too far? Dietary strategies for the prevention and treatment of NAFLD

MP Moore, RP Cunningham, RJ Dashek, JM Mucinski… - …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has
increased in recent years, concurrent with rising rates of obesity and other metabolic …