Background The clinical utility of serum procalcitonin levels in guiding antibiotic treatment
decisions in patients with sepsis remains unclear. This patient-level meta-analysis based on …

Modern burn care has led to unprecedented survival rates in burn patients whose injuries
were fatal a few decades ago. Along with improved survival, new challenges have emerged …

Rationale: Although early antimicrobial discontinuation guided by procalcitonin (PCT) has
shown decreased antibiotic consumption in lower respiratory tract infections, the outcomes …

Background Procalcitonin (PCT)-guided antibiotic discontinuation appears to decrease
antibiotic use in critically ill patients, but its impact on survival remains less certain. Methods …

Background This study assessed the ability of mid-regional proadrenomedullin (MR-
proADM) in comparison to conventional biomarkers (procalcitonin (PCT), lactate, C-reactive …

Sepsis, defined as an infection with dysregulated host response leading to life‐threatening
organ dysfunction, continues to carry a high potential for morbidity and mortality in children …

BACKGROUND Sepsis remains a major clinical challenge for which successful treatment
requires greater precision in identifying patients at increased risk of adverse outcomes …

This review aims to summarize current progress in the management of critically ill, using
biomarkers as guidance for antimicrobial treatment with a focus on antimicrobial …

Background The definition of sepsis has evolved over time, along with the clinical and
scientific knowledge behind it. For years, sepsis was defined as a systemic inflammatory …

Procalcitonin (PCT) is a peptide measurable in serum which becomes elevated in response
to bacterial infection. Multiple trials have explored the safety and efficacy of using PCT as a …