Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy

F Cofano, M Boido, M Monticelli, F Zenga… - International journal of …, 2019 - mdpi.com
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial
phase in the pathophysiological process of SCI concerns the well-known secondary injury …

Dental pulp stem cell-derived secretome and its regenerative potential

JK Bar, A Lis-Nawara, PG Grelewski - International journal of molecular …, 2021 - mdpi.com
The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of
various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo …

Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced …

V Bodart-Santos, LRP de Carvalho… - Stem cell research & …, 2019 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have been explored as promising
tools for treatment of several neurological and neurodegenerative diseases. MSCs release …

[HTML][HTML] Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action

F Pischiutta, E Caruso, H Cavaleiro, AJ Salgado… - Experimental …, 2022 - Elsevier
The severity and long-term consequences of brain damage in traumatic brain injured (TBI)
patients urgently calls for better neuroprotective/neuroreparative strategies for this …

Paracrine effects of mesenchymal stem cells in ischemic stroke: Opportunities and challenges

A Asgari Taei, P Khodabakhsh, S Nasoohi… - Molecular …, 2022 - Springer
It is well acknowledged that neuroprotective effects of transplanted mesenchymal stem cells
(MSCs) in ischemic stroke are attributed to their paracrine-mediated actions or bystander …

Therapeutic potential of astrocyte transplantation

N Hastings, WL Kuan, A Osborne… - Cell …, 2022 - journals.sagepub.com
Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it
promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of …

Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis

X Liang, F Lin, Y Ding, Y Zhang, M Li, X Zhou… - Stem cell research & …, 2021 - Springer
Abstract Background Mesenchymal stem cells (MSCs) can improve cutaneous wound
healing via the secretion of growth factors. However, the therapeutic efficacy of MSCs varies …

KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration

L Chen, K Shi, N Ditzel, W Qiu, F Figeac… - Nature …, 2023 - nature.com
Upon transplantation, skeletal stem cells (also known as bone marrow stromal or
mesenchymal stem cells) can regulate bone regeneration by producing secreted factors …

Combined cell-based therapy strategies for the treatment of Parkinson's disease: focus on mesenchymal stromal cells

J Rodríguez-Pallares, M García-Garrote… - Neural Regeneration …, 2023 - journals.lww.com
Parkinson's disease is a neurodegenerative condition characterized by motor impairments
caused by the selective loss of dopaminergic neurons in the substantia nigra. Levodopa is …

Secretome as a Tool to Treat Neurological Conditions: Are We Ready?

AV da Silva, I Serrenho, B Araújo, AM Carvalho… - International Journal of …, 2023 - mdpi.com
Due to their characteristics, mesenchymal stem cells (MSCs) are considered a potential
therapy for brain tissue injury or degeneration. Nevertheless, despite the promising results …