Braak's hypothesis has been extremely influential over the last two decades. However,
neuropathological and clinical evidence suggest that the model does not conform to all …

Parkinson's disease is a neurodegenerative disorder involving the basal ganglia that results
in a host of motor and cognitive deficits. Dopamine-replacement therapy ameliorates some …

Parkinson's disease (PD) is associated with diverse clinical manifestations including motor
and non-motor signs and symptoms, and emerging biomarkers. We aimed to reveal the …

Parkinson's disease (PD) is a critical neurological ailment that affects millions of individuals
worldwide. A correct diagnosis of Parkinson's disease is required for effective treatment …

Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of
connected brain regions can be the source of these deficits. The aim of the present study …

Background Cognitive symptoms are common in patients with Parkinson's disease.
Characterization of a patient's cognitive profile is an essential step toward the identification …

Background Clinical variability in the Parkinson's disease phenotype suggests the existence
of disease subtypes. We investigated whether distinct anatomical patterns of atrophy can be …

Parkinson's disease is a neurodegenerative disorder characterized by changes to
dopaminergic function in the striatum and a range of cognitive and motor deficits …

Background and purpose Recent application of the mild cognitive impairment concept to
Parkinson disease (PD) has proven valuable in identifying patients at risk of dementia …

Introduction Clinical presentation and progression of cognitive disorders in Parkinson's
disease (PD) is heterogeneous. Our objective was to confirm prospectively a previous …