Millions of people suffer from a wide variety of ocular diseases, many of which lead to
irreversible blindness. The leading causes of irreversible blindness in the elderly—age …

Purpose.: Glaucoma is a leading cause worldwide of blindness and visual impairment.
Transforming growth factor-β2 (TGFβ2) has been implicated in the pathogenesis of primary …

Glaucoma is a neurodegenerative disease with retinal ganglion cell (RGC) loss, optic nerve
degeneration and subsequent vision loss. There are about 30 different subtypes of RGCs …

Lentiviral vectors are promising tools for the treatment of chronic retinal diseases including
glaucoma, as they enable stable transgene expression. We examined whether simian …

Acute high IOP ischemia–reperfusion induces the loss of retinal ganglion cells, supporting
the hypothesis that the condition of ischemia–reperfusion contributes to the induction and …

purpose. To determine whether inducible nitric oxide synthase (NOS-2) is involved in
glaucomatous optic neuropathy. methods. Chronic elevation of rat intraocular pressure (IOP) …

Abstract Background Retinal ganglion cells (RGCs) are responsible for the transmission of
visual signals to the brain. Progressive death of RGCs occurs in glaucoma and several other …

purpose. To search for and validate potential molecular pathogenic mechanisms in the
trabecular meshwork (TM) responsible for the elevated intraocular pressure (IOP) …

Glaucoma is a neurodegenerative disease with elevated intraocular pressure as one of the
major risk factors. Glaucoma leads to irreversible loss of vision and its progression involves …

Intraocular pressure (IOP)-lowering effects of investigational antiglaucoma drugs often need
comparison with existing drugs, but detailed data showing comparative efficacy of …