Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

Pericytes are specialized cells located in close proximity to endothelial cells within the
microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls …

Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

BACKGROUND: Pericytes have been implicated in tissue repair, remodeling, and fibrosis.
Although the mammalian heart contains abundant pericytes, their fate and involvement in …

Diseases of the heart and the kidney, including heart failure and chronic kidney disease, can
dramatically impair life expectancy and the quality of life of patients. The heart and kidney …

Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to
what extent endothelial cells also might contribute. We detected increased expression of the …

Millions of cardiomyocytes die immediately after myocardial infarction, regardless of whether
the culprit coronary artery undergoes prompt revascularization. Residual ischaemia in the …

The immune and fibrotic responses have evolved to work in tandem to respond to pathogen
clearance and promote tissue repair. However, excessive immune and fibrotic responses …

Introduction Guidelines advise ongoing follow-up of patients after hypertensive disorders of
pregnancy (HDP) to assess cardiovascular risk and manage future patient-specific …