The renin-angiotensin system plays an important role in the regulation of arterial blood
pressure and in the development of some forms of clinical and experimental hypertension. It …

I. Introduction A ngiotensin (ANG II) was discovered about 50 yr ago (1, 2), and a complete
peripheral system for the formation and metabolism of ANG II was soon characterized. It was …

Sex has an important influence on blood pressure (BP) regulation. There is increasing
evidence that sex hormones interfere with the renin-angiotensin system. Thus the purpose of …

The renin–angiotensin–aldosterone system (RAAS) impacts cardiovascular homeostasis via
direct actions on peripheral blood vessels and via modulation of the autonomic nervous …

Considerable evidence now indicates that a separate and distinct renin-angiotensin system
(RAS) is present within the brain. The necessary precursors and enzymes required for the …

We have generated a transgenic model consisting of both the human renin and human
angiotensinogen genes to study further the role played by the renin-angiotensin system in …

Exercise training (EX) has become an important modality capable of enhancing the quality
of life and survival of patients with chronic heart failure (CHF). Although 4 wk of EX in …

During angiotensin II (Ang II)-induced elevation of arterial pressure, there is an attenuation
of the baroreflex control of heart rate (HR), but the site of this action of Ang II on the …

Moderate exercise training (Ex) enhances work capacity and quality of life in patients with
chronic heart failure (CHF). We investigated the autonomic components of resting heart rate …

Several brain regions are proposed as contributing to chronic sympatho-excitatory effects of
elevated circulating angiotensin II. However, earlier c-Fos studies have been limited to acute …