Preeclampsia (PE) is a high-prevalence pregnancy disease characterized by placental
insufficiency, gestational hypertension, and proteinuria. Overexpression of the A isoform of …

Cholesterol is the only lipid whose absorption in the gastrointestinal tract is limited by gate‐
keeping transporters and efflux mechanisms, preventing its rapid absorption and …

Background Ischemic postconditioning (IPO) has been demonstrated to attenuate
ischemia/reperfusion (I/R) injury in the heart and brain, its roles to liver remain to be defined …

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that activates the transcription of
genes and is responsible for progression of cell survival and proliferation. The synthesis of …

Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy.
Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic …

Methylation of lysine residues on histone tails is an important epigenetic modification that is
dynamically regulated through the combined effects of methyltransferases and …

Exposure to limiting oxygen in cells and tissues induce the stabilization and transcriptional
activation of the hypoxia-inducible factor 1 alpha (HIF-1α) protein, a key regulator of the …

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, is
one of the key functional and regulatory sites of the mammalian energy metabolism. Owing …

The activity of hypoxia-inducible factor 1 (HIF-1) is primarily determined by stability
regulation of its α subunit, which is stabilized under hypoxia but degraded during normoxia …

I would like to thank the Royal Society for inviting me to deliver the Croonian Lecture. In so
doing, the Society is adding my name to a list of very distinguished scientists who, since …