Abstract Hypoxia-inducible factor-1 (HIF-1), an essential promoter of tumor progression, has
attracted increasing attention as a therapeutic target. In addition to hypoxic cellular …

The transcription factor hypoxia-inducible factor-1 (HIF-1) is critical for erythropoietin and
other factors involved in the adaptation of the organism to hypoxic stress. Conflicting results …

There is extensive evidence that the restoration of blood flow following cerebral ischemia
contributes greatly to the pathophysiology of ischemia mediated brain injury. The initiating …

Production of nitric oxide (NO) has been demonstrated in several malignancies, however its
role remains not fully understood, specifically in relation to the metabolic and functional …

Lipopolysaccharide (LPS)-induced acute hepatotoxicity is significantly associated with
oxidative stress. Astaxanthin (AST), a xanthophyll carotenoid, is well known for its potent …

Recent evidence from experimental and clinical studies links the development of
intratumoral hypoxia and oxidative stress with malignant progression. Cellular adaptation …

Widespread expression of the α-subunit of hypoxia-inducible factor (HIF-1α) was observed
in samples of human oral squamous cell carcinoma. In all the cases, this was accompanied …

Aims: In addition to nitric oxide and carbon monoxide, hydrogen sulfide (H2S) is an
endogenously synthesized gaseous molecule that acts as an important signaling molecule …

Damage to osteochondral (OC) tissues can lead to pain, loss of motility, and progress to
osteoarthritis. Tissue engineering approaches offer the possibility of replacing damaged …

Aims: The nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NFE2L2/NRF2) pathway
contributes to the environmental resistance of cancers by enhancing the antioxidant …