Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a
multitude of pathways across species, but it remains challenging to understand which of …

Male obesity in reproductive-age men has nearly tripled in the past 30 y and coincides with
an increase in male infertility worldwide. There is now emerging evidence that male obesity …

Rett syndrome (RTT) is a neurological disorder caused by mutations in the X-linked gene
methyl-CpG-binding protein 2 (MECP2), a ubiquitously expressed transcriptional regulator …

To study allele‐specific expression (ASE) and binding (ASB), that is, differences between
the maternally and paternally derived alleles, we have developed a computational pipeline …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

Differentiated sex chromosomes in mammals and other vertebrates evolved independently
but in strikingly similar ways. Vertebrates with differentiated sex chromosomes share the …

Antimicrobial peptides are increasingly recognized as a critical first line of defence against
many pathogens and have been isolated from epithelial tissues and blood cells of many …

Inherited retinal diseases (IRDs) are a group of heterogeneous conditions that cause
progressive vision loss, typically due to monogenic mutations. Female carriers of X-linked …

The science of genetics is undergoing a paradigm shift. Recent discoveries, including the
activity of retrotransposons, the extent of copy number variations, somatic and chromosomal …

Methylation of DNA is a biochemical modification that can influence gene expression and is
involved in inactivating one of the two X chromosomes in women. Evidence that has …