The success of immune checkpoint blockade in patients with a wide variety of malignancies
has changed the treatment paradigm in oncology. However, combination therapies with …

Background Every day the skin is constantly exposed to several harmful factors that induce
oxidative stress. When the cells are incapable to maintain the balance between antioxidant …

Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …

Wound healing is a complex event that develops in three overlapping phases: inflammatory,
proliferative, and remodeling. These phases are distinct in function and histological …

Wound healing is a complex physiological process comprised of discrete but inter-related
and overlapping stages, requiring exact timing and regulation to successfully progress, yet …

Orchestrating when and how the cutaneous innate immune system should respond to
commensal or pathogenic microbes is a critical function of the epithelium. The cutaneous …

Significance: Over the years, it has become clear that, in addition to performing their regular
duties in immune defense, the innate and adaptive arms of the immune system are important …

Immune cells have emerged as powerful regulators of regenerative as well as pathological
processes. The vast majority of regenerative immunoengineering efforts have focused on …

Chronic injury often triggers maladaptive wound healing responses leading to the
development of tissue fibrosis and subsequent organ malfunction. Inflammation is a key …

Significance: Inflammation is an integral part of immune response and supports optimal
wound healing in adults. Inflammatory cells such as neutrophils, macrophages, dendritic …