The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …

Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain
without evident clinical symptoms. Once in the central nervous system (CNS), the virus can …

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million
people worldwide, with increasing incidence in westernized countries,. To elucidate the …

The cross-reactivity of T cells with pathogen-and self-derived peptides has been implicated
as a pathway involved in the development of autoimmunity. However, the mechanisms that …

Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-
cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging clinical …

The post-translational modification citrullination has been proposed to play a role in the
pathogenesis of multiple sclerosis (MS). Myelin basic protein (MBP) is a candidate …

Numerous studies relate the onset and severity of multiple sclerosis (MS) with viral
infections. Herpes simplex virus type 1 (HSV-1), which is neurotropic and highly prevalent in …

Highlights•Stable cell lines were used for secreted, membrane and cytosolic
proteins.•Transposons and phage ΦC31 integrases enhance chromosomal integration of …

ABSTRACT The ATLAS (Altered TCR Ligand Affinities and Structures) database
(https://zlab. umassmed. edu/atlas/web/) is a manually curated repository containing the …