Tumor cells reside in a highly complex and heterogeneous tumor microenvironment (TME),
which is composed of a myriad of genetically stable non-cancer cells, including fibroblasts …

Cancer immunotherapies have rapidly changed the therapeutic landscape for cancer.
Nevertheless, most of the patients show innate or acquired resistance to these therapies …

The low efficiency of currently-used anti-cancer therapies poses a serious challenge,
especially in the case of malignant melanoma, a cancer characterized by elevated …

Simple Summary The response to pharmacological treatments is deeply influenced by the
tight interactions between the tumor cells and the microenvironment. In this review we …

A fundamental concern of the majority of cancer scientists is related to the identification of
mechanisms involved in the evolution of neoplastic cells at the cellular and molecular level …

Cancer is a complex disease of multiple alterations occuring at the epigenomic, genomic,
transcriptomic, proteomic and/or metabolic levels. The contribution of genetic mutations in …

Kidney fibrosis initiates at certain focal sites in which the fibrogenic niche provides a
specialized microenvironment that facilitates fibroblast activation and proliferation. However …

Background Macrophages take center stage in the tumor microenvironment, a niche
composed of extracellular matrix and a heterogeneous group of cells, including immune …

Tumor metastasis is still the leading cause of melanoma mortality. Luteolin, a natural
flavonoid, is found in fruits, vegetables, and medicinal herbs. The pharmacological action …

Tumour microenvironment is a complex system comprising cells and molecules that will
provide the necessary conditions for tumour development and progression. Cells residing in …