Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

AlphaFold has burst into our lives. A powerful algorithm that underscores the strength of
biological sequence data and artificial intelligence (AI). AlphaFold has appended projects …

Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

The emergence of SARS-CoV-2 causing the COVID-19 pandemic, has highlighted how a
combination of urgency, collaboration and building on existing research can enable rapid …

Finding new drugs usually consists of five main stages: 1) a pre-discovery stage in which
basic research is performed to try to understand the mechanisms leading to diseases and …

Mitophagy impairment and oxidative stress are cardinal pathological hallmarks in
Parkinson's disease (PD), a common age-related neurodegenerative condition. The specific …

Canakinumab is an anti-interleukin-1β monoclonal antibody approved for use in a range of
immune-related disorders. During the clinical investigation (CANTOS trial) for prevention of …

The capacity for social media to influence the utilization of re-purposed medicines to
manage COVID-19, despite limited availability of safety and efficacy data, is a cause for …

The off-target toxicity of drugs targeted to proteins imparts substantial health and economic
costs. Proteome interaction studies can reveal off-target effects with unintended proteins; …