[HTML][HTML] Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

[HTML][HTML] Advances of the small molecule drugs regulating fibroblast-like synovial proliferation for rheumatoid arthritis

Y Tong, X Li, Q Deng, J Shi, Y Feng… - Frontiers in Pharmacology, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a type of chronic autoimmune and inflammatory disease. In the
pathological process of RA, the alteration of fibroblast-like synoviocyte (FLS) and its related …

[HTML][HTML] FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis

D Guo, C Lin, Y Lu, H Guan, W Qi, H Zhang, Y Shao… - Bone Research, 2022 - nature.com
Increasing evidence shows that adipokines play a vital role in the development of
rheumatoid arthritis (RA). Fatty acid-binding protein 4 (FABP4), a novel adipokine that …

[HTML][HTML] Influence of dietary vitamin E and selenium supplementation on broilers subjected to heat stress, Part II: oxidative stress, immune response, gut integrity, and …

A Calik, NK Emami, G Schyns, MB White, MC Walsh… - Poultry Science, 2022 - Elsevier
This study evaluated the effects of vitamin E (Vit E) and selenium (Se) supplementation on
mRNA abundance of antioxidant, immune response, and tight junction genes, as well as …

[HTML][HTML] METTL3 promotes activation and inflammation of FLSs through the NF-κB signaling pathway in rheumatoid arthritis

W Shi, Y Zheng, S Luo, X Li, Y Zhang, X Meng… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA), a common autoimmune disease, is extremely damaging to
human health. Fibroblast-like synoviocytes (FLSs) have a vital role in the occurrence and …

[HTML][HTML] Immunomodulatory roles of metalloproteinases in rheumatoid arthritis

Y Bian, Z Xiang, Y Wang, Q Ren, G Chen… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic, autoimmune pathology characterized by persistent
synovial inflammation and gradually advancing bone destruction. Matrix metalloproteinases …

[HTML][HTML] Targeting AhR as a novel therapeutic modality against inflammatory diseases

AS Cannon, PS Nagarkatti, M Nagarkatti - International Journal of …, 2021 - mdpi.com
For decades, activation of Aryl Hydrocarbon Receptor (AhR) was excluded from
consideration as a therapeutic approach due to the potential toxic effects of AhR ligands and …

Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: A systematic review

GR Gandhi, G Jothi, T Mohana, ABS Vasconcelos… - Phytomedicine, 2021 - Elsevier
Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease
causing severe locomotor disability and deterioration in the quality of life. Existing treatments …

The lncRNAs UCA1 and CRNDE target miR-145/TLR4/NF-қB/TNF-α axis in acetic acid-induced ulcerative colitis model: The beneficial role of 3, 3-Diindolylmethane

NA El-Boghdady, S Abd El-Hakk… - International …, 2023 - Elsevier
Introduction Ulcerative colitis (UC) is a chronic disease that alters the colonic and rectal
mucosa. The high prevalence rates of UC make it a worldwide healthcare problem …

In situ-activated phospholipid-mimic artemisinin prodrug via injectable hydrogel Nano/microsphere for rheumatoid arthritis therapy

Y Du, C Li, Y Zhang, W Xiong, F Wang, J Wang… - Research, 2022 - spj.science.org
In situ-activated therapy is a decent option for localized diseases with improved efficacies
and reduced side effects, which is heavily dependent on the local conversion or activation of …