Pharmacological inhibition of the nod-like receptor family pyrin domain containing 3 inflammasome with MCC950

SE Corcoran, R Halai, MA Cooper - Pharmacological reviews, 2021 - ASPET
Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1 β and IL-18 and induces …

NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer

SS Faria, S Costantini, VCC de Lima… - Journal of Biomedical …, 2021 - Springer
Breast cancer is the most diagnosed malignancy in women. Increasing evidence has
highlighted the importance of chronic inflammation at the local and/or systemic level in …

NLRP3 inflammasome: The rising star in cardiovascular diseases

Y Zheng, L Xu, N Dong, F Li - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are the prevalent cause of mortality around the world.
Activation of inflammasome contributes to the pathological progression of cardiovascular …

Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome‐Induced Pyroptosis via Inhibiting the TLR4/NF‐κB/PFKFB3 Signaling in …

Y Zhang, W Liu, Y Zhong, Q Li, M Wu… - Oxidative Medicine …, 2021 - Wiley Online Library
NOD‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasome‐
mediated pyroptosis is a crucial event in the preeclamptic pathogenesis, tightly linked with …

Preeclampsia is a syndrome with a cascade of pathophysiologic events

W Gyselaers - Journal of clinical medicine, 2020 - mdpi.com
This review integrates the currently available information on the molecular, cellular, and
systemic mechanisms involved in the pathophysiology of preeclampsia. It highlights that the …

Hypoxia-inducible factor 1 and preeclampsia: a new perspective

SM Albogami, HM Al-Kuraishy, TJ Al-Maiahy… - Current Hypertension …, 2022 - Springer
Abstract Purpose of Review Preeclampsia (PE) is a serious and distinct type of pregnancy-
induced hypertension, with an incidence of 2–8% worldwide. PE is defined as pregnancy …

The crosstalk between NLRP3 inflammasome and gut microbiome in atherosclerosis

XN Zhang, ZL Yu, JY Chen, XY Li, ZP Wang… - Pharmacological …, 2022 - Elsevier
Atherosclerosis (AS) is chronic pathological process based on the inflammatory reaction
associated with factors including vascular endothelial dysfunction, inflammation, and …

Placentas from Women with Late-Onset Preeclampsia Exhibit Increased Expression of the NLRP3 Inflammasome Machinery

LM Garcia-Puente, O Fraile-Martinez… - Biomolecules, 2023 - mdpi.com
Pre-eclampsia is a harmful and potentially lethal medical condition during pregnancy
clinically diagnosed by hypertension and commonly accompanied by proteinuria and …

Etiological value of sterile inflammation in preeclampsia: is it a non-infectious pregnancy complication?

S Banerjee, Z Huang, Z Wang, A Nakashima… - Frontiers in Cellular …, 2021 - frontiersin.org
Understanding of sterile inflammation and its associated biological triggers and diseases is
still at the elementary stage. This becomes more warranted in cases where infections are not …

Melatonin: the placental antioxidant and anti-inflammatory

TT Joseph, V Schuch, DJ Hossack… - Frontiers in …, 2024 - frontiersin.org
Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone with many
physiological and biological roles. Melatonin is an antioxidant, anti-inflammatory, free …