Immune cells undergo rapid and extensive metabolic changes during inflammation. In
addition to contributing to energetic and biosynthetic demands, metabolites can also …

The first line of defense against viral infection of the host cell is the cellular lipid membrane,
which is also a crucial first site of contact for viruses. Lipids may sometimes be used as viral …

The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to
clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral …

Hypervirulent Klebsiella pneumoniae (hvKP) is a highly lethal opportunistic pathogen that
elicits more severe inflammatory responses compared to classical Klebsiella pneumoniae …

In recent years, especially since the outbreak of the severe acute respiratory syndrome
coronavirus 2 pandemic, the cell-permeable itaconate derivative 4-octyl itaconate (4-OI) has …

Mitochondrial metabolites and their derivatives have been the focus of recent efforts to
develop new anti-inflammatory therapeutics. The widely used therapeutic agents dimethyl …

Abstract Background Astragaloside IV (AST-IV), as an effective active ingredient of
Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV inhibits the …

Background In the past decades, extensive research has been conducted to identify new
drug targets for the treatment of Herpes simplex virus type 1 (HSV-1) infections. However …

Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular
resistance, imposing overload on the right ventricle (RV) and imbalance of redox state. Our …