Systemic rheumatic diseases (SRDs) are chronic, inflammatory, autoimmune disorders with
the presence of autoantibodies that may affect any organ or system. Liver dysfunction in …

Background & Aims The aim of this study was to quantify the global epidemiology of primary
sclerosing cholangitis (PSC), alongside the incidence of liver transplantation, cancer, and …

Background & Aims The Primary Biliary Cholangitis (PBC) Obeticholic Acid (OCA)
International Study of Efficacy (POISE) randomized, double-blind, placebo-controlled trial …

Autoimmune hepatitis is a chronic inflammatory disease of the liver. The etiology is partly
unknown and commonly affects women of all ages. It is characterised by increase in …

Abstract Purpose Immune checkpoint inhibitors (ICIs) are associated with a unique set of
immune-related adverse events (irAEs). Few studies have evaluated the risk factors and …

Severe diseases like cirrhosis and liver failure can be developed from primary biliary
cholangitis (PBC). Endothelin-2 (EDN2) and endothelin receptor B (EDNRB) are related to …

Rare diseases, also known as orphan diseases, are a group of diseases that affect a
relatively small number of people. Low incidence rates, atypical symptoms, imperfect …

Autoimmune hepatitis is an inflammatory disease of the liver of unknown cause that may
progress to liver cirrhosis and end stage liver failure if diagnosis is overlooked and treatment …

We read with interest the work by Mansoor et al 1 regarding the outcomes of COVID-19 in
coeliac disease. The impact of pre-existing chronic liver diseases on COVID-19 outcomes …

Background & aims Autoimmune hepatitis (AIH) is characterized by hepatocyte destruction,
leading to lymphocyte and macrophage accumulation in the liver. Macrophages are key …