Novel and emerging therapies for inflammatory bowel disease

B Al-Bawardy, R Shivashankar… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease are
chronic, relapsing and remitting disorders of intestinal inflammation with potential systemic …

Drug delivery to macrophages: a review of targeting drugs and drug carriers to macrophages for inflammatory diseases

W He, N Kapate, CW Shields IV, S Mitragotri - Advanced drug delivery …, 2020 - Elsevier
Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Breaking the therapeutic ceiling in drug development in ulcerative colitis

D Alsoud, B Verstockt, C Fiocchi… - The lancet …, 2021 - thelancet.com
Increased knowledge of the intricate pathogenesis of ulcerative colitis has triggered an
advance in drug development during the past two decades, resulting in the advent of several …

Nanoparticle-mediated drug delivery systems for the treatment of IBD: current perspectives

C Yang, D Merlin - International journal of nanomedicine, 2019 - Taylor & Francis
Inflammatory bowel disease (IBD), which mainly consists of Crohn's disease and ulcerative
colitis, is a chronic and relapsing inflammatory condition of the gastrointestinal tract. The …

History of inflammatory bowel diseases

GC Actis, R Pellicano, S Fagoonee… - Journal of clinical …, 2019 - mdpi.com
Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the
intestinal mucosa and unknown etiology. In this review, we identified three main eras in the …

The role of tissue-resident macrophages in the development and treatment of inflammatory bowel disease

S Ma, J Zhang, H Liu, S Li, Q Wang - Frontiers in cell and …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a
refractory disease with many immune abnormalities and pathologies in the gastrointestinal …

[HTML][HTML] Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease

QL Chen, HR Yin, QY He, Y Wang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
The incidence and prevalence of inflammatory bowel disease (IBD) are increasing
worldwide. Current approved medication for IBD treatment in the clinic mainly includes …

Oncostatin M is a biomarker of diagnosis, worse disease prognosis, and therapeutic nonresponse in inflammatory bowel disease

S Verstockt, B Verstockt, K Machiels… - Inflammatory bowel …, 2021 - academic.oup.com
Abstract Background Oncostatin M (OSM) has been implicated in the pathogenesis of
inflammatory bowel disease (IBD) and as a marker for nonresponsiveness to anti-tumor …

Management of non-response and loss of response to anti-tumor necrosis factor therapy in inflammatory bowel disease

J Marsal, M Barreiro-de Acosta, I Blumenstein… - Frontiers in …, 2022 - frontiersin.org
Anti-tumor necrosis factor (anti-TNF) therapy has been successfully used as first-line
biologic treatment for moderate-to-severe inflammatory bowel disease (IBD), in both “step …

Exploring the pipeline of novel therapies for inflammatory bowel disease; state of the art review

Y Zurba, B Gros, M Shehab - Biomedicines, 2023 - mdpi.com
Crohn's disease (CD) and ulcerative colitis (UC), known as inflammatory bowel diseases
(IBD), are characterized by chronic inflammation of the gastrointestinal tract. Over the last …