Genomic technologies have led to tremendous gains in understanding how pathogens
function, evolve and interact. Pathogen diversity is now measurable at high precision and …

Antimicrobial resistance is a major threat to human health. Since the 2000s, computational
tools for predicting infectious diseases have been greatly advanced; however, efforts to …

Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus
pneumoniae have previously been confounded by high rates of recombination. Sequencing …

Disease and community ecology share conceptual and theoretical lineages, and there has
been a resurgence of interest in strengthening links between these fields. Building on recent …

Tackling antibiotic resistance necessitates deep understanding of how resource competition
within and between species modulates the fitness of resistant microbes. Recent advances in …

Antibiotic use is a primary driver of antibiotic resistance. However, antibiotic use can be
distributed in different ways in a population, and the association between the distribution of …

Understanding how changes in antibiotic consumption affect the prevalence of antibiotic
resistance in bacterial pathogens is important for public health. In a number of bacterial …

The spread of antibiotic resistance, a major threat to human health, is poorly understood.
Simple population-level models of bacterial transmission predict that above a certain rate of …

Streptococcus pneumoniae has more than 95 serotypes, each of which presumably can
cause sepsis, meningitis, pneumonia, and acute otitis media. Pneumococcal conjugate …

The evolution of resistance to antibiotics is a major public health problem and an example of
rapid adaptation under natural selection by antibiotics. The dynamics of antibiotic resistance …