Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

Transcriptional and epigenetic embryonic programs can be reactivated in cancer cells. As
result, a specific subset of undifferentiated cells with stem‐cells properties emerges and …

Sox9 is a transcription factor expressed in most solid tumors. However, the molecular
mechanisms underlying Sox9 function during tumorigenesis remain unclear. Here, using a …

SRY-related high-mobility group box 9 (SOX9) is an indispensable transcription factor that
regulates multiple developmental pathways related to stemness, differentiation, and …

Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …

The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely
defined and the central regulators are unknown. By bioinformatic analysis of a human PCSC …

Aim As one of the most common and lethal carcinomas, hepatocellular carcinoma (HCC) is
a global health concern and affects millions of people worldwide. Current treatments for …

Hypoxia contributes to pancreatic cancer progression and promotes its growth and invasion.
Previous research principally focused on hypoxia-inducible factor-1 alpha (HIF-1α) and HIF …

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor with limited
therapeutic options. Glioma stem cell (GSC) is thought to be greatly responsible for glioma …

Glioblastoma is the most common primary central nervous system tumor in adults.
Angiotensin II receptor blockers (ARBs) are broadly applied to treat hypertension. Moreover …