The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …

Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of
the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids …

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for
regeneration. Normally providing strong regenerative support, these cells fail in aging …

The hedgehog pathway, initially discovered by two Nobel laureates Drs E Wieschaus and C
Nusslein-Volhard in Drosophila, is a major regulator for cell differentiation, tissue polarity …

Hedgehog signaling is essential for tissue development and stemness, and its deregulation
has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result …

A surprisingly large and unrelated number of human tumors depend on sustained
HEDGEHOG-GLI (HH-GLI) signaling for growth. This includes cancers of the skin, brain …

The characterization of cells with tumour initiating potential is significant for advancing our
understanding of cancer and improving therapy. Aggressive, triple‐negative breast cancers …

Canonical Hedgehog (HH) signaling leads to the regulation of the GLI code: the sum of all
positive and negative functions of all GLI proteins. In humans, the three GLI factors encode …

Abstract Inhibition of Hedgehog (HH)/GLI signalling in cancer is a promising therapeutic
approach. Interactions between HH/GLI and other oncogenic pathways affect the strength …

Hedgehog pathway regulates tissue patterning and cell proliferation. Gli1 transcription factor
is the major effector of Hedgehog signaling and its deregulation is often associated to …