Background The nuclear transcription factor c-Jun is preferentially expressed in basal-cell
carcinoma. Dz13 is a deoxyribozyme that targets JUN messenger RNA and has inhibited the …

Basal cell carcinoma (BCC) of the skin represents the most common malignancy in humans.
MicroRNAs (miRNAs), small regulatory RNAs with pleiotropic function, are commonly …

The hedgehog (Hh)/glioma-associated oncogene (GLI) signaling network is among the most
important and fascinating signal transduction systems that provide critical functions in the …

Hedgehog (HH) signaling is an evolutionarily conserved pathway that is crucial for growth
and tissue patterning during embryonic development. It is mostly quiescent in the adult …

Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor
in many human malignancies. Signal strength, target gene specificity, and oncogenic activity …

Sonic hedgehog (Shh) signaling is critically important for embryogenesis and other cellular
processes in which GLI transcription factors mediate the terminal effects of the pathway …

Background The GLI transcription factors, mediators of the hedgehog signal bind with high
affinity to the consensus sequence GACCACCCA. The affinity of variant single substitutions …

Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in
adults. Despite several advances, little is known about GBM–specific aberrant signalling …

The highly conserved Hedgehog/GLI signaling pathway regulates multiple aspects of
embryonic development and plays a decisive role in tissue homeostasis and the …

Background & Aims To improve outcomes of two-staged hepatectomies for large/multiple
liver tumors, portal vein ligation (PVL) has been combined with parenchymal transection …