Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes
has grown substantially, particularly with regard to disease prediction and heterogeneity …

Diabetic nephropathy is the leading cause of end-stage renal disease. Patients with diabetic
nephropathy have a high cardiovascular risk, comparable to patients with coronary heart …

Diabetic nephropathy constitutes a devastating complication in patients with type 1 diabetes
mellitus, and its diagnosis is traditionally based on microalbuminuria. The aim of this review …

Recent advances in defining the molecular signaling pathways that regulate the
phagocytosis of apoptotic cells have improved our understanding of this complex and …

Introduction: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease
(CKD) and end-stage renal disease (ESRD). Beyond the new anti-diabetic drugs that …

A new model of diabetic nephropathy in type 1 diabetes emerged from our studies of Joslin
Clinic patients. The dominant feature is progressive renal decline, not albuminuria. This …

Diabetic nephropathy (DN) is a major cause of end-stage renal disease and affects a large
number of individuals with diabetes. However, the development of specific treatments for DN …

Identification of sequence variants robustly associated with predisposition to diabetic kidney
disease (DKD) has the potential to provide insights into the pathophysiological mechanisms …