Significant progress has been made over the years in the development of in vitro-
engineered substitutes that mimic human skin, either to be used as grafts for the …

Although the genetic basis of tumorigenesis may vary greatly between different cancer
types, the cellular and molecular steps required for metastasis are similar for all cancer cells …

Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer
prognosis than young. This may be due to accumulated cellular damage, decreases in …

The molecular biology of metastatic potential in melanoma has been studied many times
previously and changes in the expression of many genes have been linked to metastatic …

The loss of E‐cadherin expression or function in epithelial carcinomas has long been
thought as a primary reason for disruption of tight epithelial cell‐cell contacts and release of …

We have shown that Wnt5A increases the motility of melanoma cells. To explore cellular
pathways involving Wnt5A, we compared gain-of-function (WNT5A stable transfectants) …

Background Several hypotheses proposed to explain the worse prognosis for older
melanoma patients include different tumor biology and diminished host response. If the latter …

The book aims to provide an introduction to mathematical models that describe the
dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for …

Therapeutic resistance and proclivity for metastasis are hallmarks of malignant melanoma.
Genetic, epidemiological and genomic investigations are uncovering the spectrum of …

Background Invasion is an important early step of cancer metastasis that is not well
understood. Developing therapeutics to limit metastasis requires the identification and …